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Gene expression of sorted Eomes+ and Eomes‒ γδ T cells from spleen of Eomes-IRES-GFP mice.

ABSTRACT: Eomesodermin (Eomes) is a transcription factor with a crucial role regulating cytotoxic function, development and survival of immune cells. Although it is known that γδ T cells can express Eomes, its function on those cells is still largely unknown. Using Eomes-IRES-GFP mice we were able to sort for Eomes+ and Eomes‒ γδ T cells populations and get their gene expression profiles, bringing light to the role of Eomes on γδ T cells.

ORGANISM(S): Mus musculus

PROVIDER: GSE85585 | GEO | 2017/04/10

SECONDARY ACCESSION(S): PRJNA338885

REPOSITORIES: GEO

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EOMES interacts with RUNX3 and BRG1 to promote innate memory cell formation through epigenetic reprogramming

Project description:Memory CD8+ T cells have the ability to provide lifelong immunity against pathogens. Although memory features generally arise after challenge with a foreign antigen, naïve CD8 single positive (SP) thymocytes may acquire phenotypic and functional characteristics of memory cells in response to cytokines such as interleukin-4. This process is associated with the induction of the T-box transcription factor Eomesodermin (EOMES). However, the underlying molecular mechanisms remain ill-defined. Using epigenomic profiling, we show that these innate memory CD8SP cells acquire only a portion of the active enhancer repertoire of conventional memory cells. This reprograming is secondary to EOMES recruitment, mostly to RUNX3-bound enhancers. Furthermore, EOMES is found within chromatin-associated complexes containing BRG1 and promotes the recruitment of this chromatin remodelling factor. Also, the in vivo acquisition of EOMES-dependent program is BRG1-dependent. In conclusion, our results support a strong epigenetic basis for the EOMES-driven establishment of CD8+ T cell innate memory program.

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Expression data from Eomes+ and Eomes- CD8 T cells following aOX40/aCTLA-4 treatment

Project description:Development, maturation, and function of CD8 T cells is regulated by transcription factor expression. Expression of the transcription factor Eomesodermin was found to be significantly increased in CD8 T cells following aOX40/aCTLA-4 immunotherapy in mice. We used microarray analysis to detail gene expression in Eomes+ and Eomes- CD8 T cells following aOX40/aCTLA-4 treatment to determin functional differences between these two populations.

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Eomes

Project description:Rattus norvegicus Eomes, eomesodermin [Source:RGD Symbol;Acc:1359706], is differentially expressed in 9 experiment(s);

| ENSRNOG00000042140 | ExpressionAtlas

Eomes

Project description:Rattus norvegicus Eomes, eomesodermin [Source:RGD Symbol;Acc:1359706], is expressed in 3 baseline experiment(s);

| ENSRNOG00000042140 | ExpressionAtlas

EOMES

Project description:Sus scrofa EOMES, eomesodermin [Source:VGNC Symbol;Acc:VGNC:87719], is differentially expressed in 1 experiment(s);

| ENSSSCG00000040057 | ExpressionAtlas

EOMES

Project description:Sus scrofa EOMES, eomesodermin [Source:VGNC Symbol;Acc:VGNC:87719], is expressed in 2 baseline experiment(s);

| ENSSSCG00000040057 | ExpressionAtlas

EOMES

Project description:Macaca mulatta EOMES, eomesodermin [Source:HGNC Symbol;Acc:HGNC:3372], is expressed in 1 baseline experiment(s);

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EOMES

Project description:Oryctolagus cuniculus EOMES, eomesodermin [Source:HGNC Symbol;Acc:HGNC:3372], is expressed in 1 baseline experiment(s);

| ENSOCUG00000000451 | ExpressionAtlas

EOMES

Project description:Equus caballus EOMES, eomesodermin [Source:VGNC Symbol;Acc:VGNC:17604], is expressed in 1 baseline experiment(s);

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EOMES

Project description:Homo sapiens EOMES, eomesodermin [Source:HGNC Symbol;Acc:HGNC:3372], is expressed in 32 baseline experiment(s);

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