Genomics

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Expression data from intestinal dendritic cells and macrophages of VDTR mice at 4 hours post diphtheria toxin administration


ABSTRACT: Recognition and removal of apoptotic cells by professional phagocytes, including dendritic cells and macrophages, preserve self-tolerance and prevent chronic inflammation and autoimmune pathologies. However the diverse array of phagocytes residing within different tissues combined with the necessarily prompt nature of apoptotic cell clearance has made it difficult to study this process in situ. Thus, the full spectrum of functions executed by tissue resident phagocytes in response to homeostatic apoptosis remains unclear. We used microarrays to characterize the transcriptome within murine intestinal dendritic cells and macrophages both before and after in situ phagocytosis of apoptotic intestinal epithelial cells.

ORGANISM(S): Mus musculus

PROVIDER: GSE85682 | GEO | 2016/11/10

SECONDARY ACCESSION(S): PRJNA339056

REPOSITORIES: GEO

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