Transcriptomics

Dataset Information

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RNA-Seq data of CD4+ T cells from mice with Type-A vs Type-B EAE


ABSTRACT: Purpose: To compare gene expression of CD4+ T cells between Type-A and Type-B EAE Method: CD4+ T cells were FACS sorted from spleens 9-day post immunization. Results: We found that Type-B EAE (NLRP3 inflammasome-dependent and IFNb treatment-resistant EAE) express high levels of CXCR2 and other chemokine receptors, which can be targeted to treat the Type-A EAE subtypes, instead of treating with IFNb. Conclusions: Altering intensity of immunization significantly impacts on gene expression patterns in T cells.

ORGANISM(S): Mus musculus

PROVIDER: GSE85946 | GEO | 2016/11/07

SECONDARY ACCESSION(S): PRJNA339814

REPOSITORIES: GEO

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