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CCAR2 is required for proliferation and tumor maintenance in human Squamous Cell Carcinoma

ABSTRACT: This study was designed to elucidate the role of CCAR2 in human Squamous Cell Carcinoma Cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE85966 | GEO | 2017/02/01

SECONDARY ACCESSION(S): PRJNA339851

REPOSITORIES: GEO

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CCAR2 Is Required for Proliferation and Tumor Maintenance in Human Squamous Cell Carcinoma.

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FGFR2 Signaling Underlies p63 Oncogenic Function in Squamous Cell Carcinoma

Project description:This study was designed to examine the requirement for the p63 transcription factor in Squamous Cell Carcinoma (SCC) tumor maintenance in an in vivo murine system. A tamoxifen-inducible Keratin 14-driven Cre recombinase transgene was used to conditionally excise p63 in advanced murine SCC tumors. These data show the context-dependent regulation of p63 target genes in cancer. Total RNA from murine Squamous Cell Carcinoma tumors was examined 1-3 days following genomic excision of TP63 in Keratin 14-expressing tumor cells.

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