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PRDM16 binding in brown adipocyte precursors [ChIP-seq]

ABSTRACT: PRDM16 is an important transcriptional regulator of brown and beige adipocyte gene programs. We discovered that PRDM16 also represses type I Interferon-stimulated genes (ISGs) in brown and beige adipocytes. ChIP-seq demonstrated that PRDM16 binds proximal to many of the regulated ISGs and this correlates with reduction in the amount of the activating mark, H3K27Ac. Together this data shows PRDM16 represses ISG expression through direct binding at promoter regions to block transcription.

ORGANISM(S): Mus musculus

PROVIDER: GSE86017 | GEO | 2017/04/10

SECONDARY ACCESSION(S): PRJNA340049

REPOSITORIES: GEO

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PRDM16 represses the type I Interferon response in adipocytes [expression profiling]

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