Genomics

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Increasing of antitumor effect of decitabine against classical Hodgkin lymphoma (cHL) by targeting decitabine-activated pro-survival pathways


ABSTRACT: We found that 5-Aza-dC/decitabine induces various prosurvival pathways (JAK-STAT-, NFkB-, MEK/ERK- and PI3K/AKTpathway) in cHL cell lines. Inhibition of these pathways with specific small molecular weight inhibitors potentiates the antitumor effect of 5-Aza-dC.

ORGANISM(S): Homo sapiens

PROVIDER: GSE86068 | GEO | 2017/08/01

SECONDARY ACCESSION(S): PRJNA340163

REPOSITORIES: GEO

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