Transcriptomics,Genomics

Dataset Information

154

Extensive Supporting Cell Proliferation and Mitotic Hair Cell Generation by In Vivo Genetic Reprogramming in the Neonatal Mouse Cochlea


ABSTRACT: We used RNA sequencing to compare the transcripts of the cochleae from control mice and from mice with β-catenin activation, Notch1 deletion, and β-catenin activation combined with Notch1 deletion in Sox2+ SCs. We identified the genes involved in the proliferation and transdifferentiation process that are either controlled by individual signaling pathways or by the combination of Wnt and Notch signaling.  Overall design: Supporting cell proliferation and mitotic hair cell generation by in vivo genetic reprogramming of Wnt and Notch pathways

INSTRUMENT(S): Illumina HiSeq 2500 (Mus musculus)

SUBMITTER: Luo Guo  

PROVIDER: GSE86204 | GEO | 2016-08-30

SECONDARY ACCESSION(S): PRJNA340885

REPOSITORIES: GEO

altmetric image

Publications

Extensive Supporting Cell Proliferation and Mitotic Hair Cell Generation by In Vivo Genetic Reprogramming in the Neonatal Mouse Cochlea.

Ni Wenli W   Lin Chen C   Guo Luo L   Wu Jingfang J   Chen Yan Y   Chai Renjie R   Li Wenyan W   Li Huawei H  

The Journal of neuroscience : the official journal of the Society for Neuroscience 20160801 33


UNLABELLED:The generation of hair cells (HCs) from the differentiation of proliferating supporting cells (SCs) appears to be an ideal approach for replacing lost HCs in the cochlea and is promising for restoring hearing after damage to the organ of Corti. We show here that extensive proliferation of SCs followed by mitotic HC generation is achieved through a genetic reprogramming process involving the activation of β-catenin to upregulate Wnt signaling, the deletion of Notch1 to downregulate Not  ...[more]

Similar Datasets

| GSE15232 | GEO
2009-05-13 | E-GEOD-15232 | ArrayExpress
2010-11-10 | GSE25222 | GEO
2007-09-24 | GSE8818 | GEO
2008-06-16 | E-GEOD-8818 | ArrayExpress
2010-11-10 | E-GEOD-25222 | ArrayExpress
2018-02-07 | PXD007909 | Pride
2019-01-11 | PXD009305 | Pride
2018-10-25 | PXD010421 | Pride
2011-01-28 | E-GEOD-26850 | ArrayExpress