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MiRNAs are required for post-induction stage sweat gland development

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE86296 | GEO | 2016/12/13

SECONDARY ACCESSION(S): PRJNA341435

REPOSITORIES: GEO

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miRNAs are required for post-induction stage sweat gland development [miRNA]

Project description:miRNAs modulate processes in development, aging and cancer formation. However, miRNA function in sweat gland development has not been previously studied. By generating skin specific Dicer knockout mice, we show that miRNAs are required for post-induction stage sweat gland development.

2016-12-13 | GSE86295 | GEO

miRNAs are required for post-induction stage sweat gland development [mRNA]

2016-12-13 | GSE86294 | GEO

miRNAs Are Required for Postinduction Stage Sweat Gland Development.

Project description: Not available

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miRNAs are required for post-induction stage sweat gland development

Project description:miRNAs are required for post-induction stage sweat gland development

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Cascade regulation of sweat gland development by Wnt, Eda and Shh pathways

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

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Eccrine sweat gland development and sweat secretion.

Project description:Eccrine sweat glands help to maintain homoeostasis, primarily by stabilizing body temperature. Derived from embryonic ectoderm, millions of eccrine glands are distributed across human skin and secrete litres of sweat per day. Their easy accessibility has facilitated the start of analyses of their development and function. Mouse genetic models find sweat gland development regulated sequentially by Wnt, Eda and Shh pathways, although precise subpathways and additional regulators require further elucidation. Mature glands have two secretory cell types, clear and dark cells, whose comparative development and functional interactions remain largely unknown. Clear cells have long been known as the major secretory cells, but recent studies suggest that dark cells are also indispensable for sweat secretion. Dark cell-specific Foxa1 expression was shown to regulate a Ca(2+) -dependent Best2 anion channel that is the candidate driver for the required ion currents. Overall, it was shown that cholinergic impulses trigger sweat secretion in mature glands through second messengers - for example InsP3 and Ca(2+) - and downstream ion channels/transporters in the framework of a Na(+) -K(+) -Cl(-) cotransporter model. Notably, the microenvironment surrounding secretory cells, including acid-base balance, was implicated to be important for proper sweat secretion, which requires further clarification. Furthermore, multiple ion channels have been shown to be expressed in clear and dark cells, but the degree to which various ion channels function redundantly or indispensably also remains to be determined.

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Cascade regulation of sweat gland development by Wnt, Eda and Shh pathways

Project description:This SuperSeries is composed of the SubSeries listed below.

2014-08-20 | GSE50863 | GEO

Reciprocal interaction between vascular niche and sweat gland promotes sweat gland regeneration.

Project description:The incorporation of vasculature is known to be effective in tissue or organ functional regeneration. However, a vague understanding of the interaction between epidermal appendages and their vascular niches is a foremost obstacle to obtaining sweat gland (SG)-specific vasculature units. Here, we map their precise anatomical connections and report that the interplay between SG cells (SGCs) and the surrounding vascular niche is key for glandular development and homeostasis maintenance. To replicate this interplay in vitro, we used three-dimensional (3D) bioprinting to generate reproducible SGC spheroids from differentiated adipose-derived mesenchymal stem cells (ADSCs). With dermal microvascular endothelial cells (DMECs), sacrificial templates made from poly (ε-caprolactone) (PCL) were fabricated to pattern the vascular niche. This interplay model promoted physiologically relevant vascularized glandular morphogenesis in vitro and in vivo. We identified a reciprocal regulatory mechanism for promoting SGs regeneration via contact-independent cell communication and direct cell-cell interactions between SGs and the vasculature. We envision the successful use of our approach for vascularized organ regeneration in the near future.

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Sweat gland organoids contribute to cutaneous wound healing and sweat gland regeneration.

Project description:Sweat glands perform a vital thermoregulatory function in mammals. Like other skin components, they originate from epidermal progenitors. However, they have low regenerative potential in response to injury. We have established a sweat gland culture and expansion method using 3D organoids cultures. The epithelial cells derived from sweat glands in dermis of adult mouse paw pads were embedded into Matrigel and formed sweat gland organoids (SGOs). These organoids maintained remarkable stem cell features and demonstrated differentiation capacity to give rise to either sweat gland cells (SGCs) or epidermal cells. Moreover, the bipotent SGO-derived cells could be induced into stratified epidermis structures at the air-liquid interface culture in a medium tailored for skin epidermal cells in vitro. The SGCs embedded in Matrigel tailored for sweat glands formed epithelial organoids, which expressed sweat-gland-specific markers, such as cytokeratin (CK) 18 and CK19, aquaporin (AQP) 5 and αATP. More importantly, they had potential of regeneration of epidermis and sweat gland when they were transplanted into the mouse back wound and claw pad with sweat gland injury, respectively. In summary, we established and optimized culture conditions for effective generation of mouse SGOs. These cells are candidates to restore impaired sweat gland tissue as well as to improve cutaneous skin regeneration.

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Repression of endogenous retroviruses is required for mammary gland development and homeostasis

Project description:This SuperSeries is composed of the SubSeries listed below.

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