Ontology highlight
ABSTRACT:
INSTRUMENT(S): [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
SUBMITTER: Mårten Fryknäs
PROVIDER: GSE86309 | GEO | 2017-07-04
SECONDARY ACCESSION(S): PRJNA341386
REPOSITORIES: GEO
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GSE86309_RAW.tar | Raw | |||
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Oncotarget 20170501 18
<h4>Background</h4>The thiosemicarbazone CD 02750 (VLX50) was recently reported as a hit compound in a phenotype-based drug screen in primary cultures of patient tumor cells. We synthesized a copper complex of VLX50, denoted VLX60, and characterized its antitumor and mechanistic properties.<h4>Materials and methods</h4>The cytotoxic effects and mechanistic properties of VLX60 were investigated in monolayer cultures of multiple human cell lines, in tumor cells from patients, in a 3-D spheroid cel ...[more]