Dataset Information


VLX60 characterization II

ABSTRACT: Microarray based mRNA profiling was used to identify the mechanism of action for the small molecule VLX60. Overall design: HCT116 cells were treated with the drug candidate VLX50 or VLX60 for 6h prior to RNA isolation

INSTRUMENT(S): [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array

SUBMITTER: Mårten Fryknäs  

PROVIDER: GSE86309 | GEO | 2017-07-04



Dataset's files

Action DRS
GSE86309_RAW.tar Raw
filelist.txt Txt
Items per page:
1 - 2 of 2
altmetric image


Mechanistic characterization of a copper containing thiosemicarbazone with potent antitumor activity.

Karlsson Henning H   Fryknäs Mårten M   Strese Sara S   Gullbo Joachim J   Westman Gunnar G   Bremberg Ulf U   Sjöblom Tobias T   Pandzic Tatjana T   Larsson Rolf R   Nygren Peter P  

Oncotarget 20170501 18

<h4>Background</h4>The thiosemicarbazone CD 02750 (VLX50) was recently reported as a hit compound in a phenotype-based drug screen in primary cultures of patient tumor cells. We synthesized a copper complex of VLX50, denoted VLX60, and characterized its antitumor and mechanistic properties.<h4>Materials and methods</h4>The cytotoxic effects and mechanistic properties of VLX60 were investigated in monolayer cultures of multiple human cell lines, in tumor cells from patients, in a 3-D spheroid cel  ...[more]

Similar Datasets

2015-05-28 | E-GEOD-58526 | BioStudies
2015-05-28 | E-GEOD-58526 | ArrayExpress
2016-12-07 | GSE84051 | GEO
2013-06-21 | E-GEOD-30141 | ArrayExpress
2011-09-08 | E-GEOD-24027 | ArrayExpress
2011-09-09 | GSE24027 | GEO
2018-01-01 | S-EPMC6256366 | BioStudies
2006-09-01 | GSE5505 | GEO
2020-01-01 | S-EPMC7017376 | BioStudies
1000-01-01 | S-EPMC4826980 | BioStudies