Genomics

Dataset Information

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Gene expression signatures in activated CD4 T cells to predict_vaccine responses


ABSTRACT: To decipher the molecular mechanisms underlying_variable_vaccine responses, T- and B-cell responses to_vaccination with a life zoster_vaccine were examined in individuals of different ages. Diminished generation of long-lived memory T cells in older individuals was mainly caused by increased T cell loss after the peak response while the expansion of antigen-specific T cells was not affected by age. Gene expression in activated CD4 T cells co-expressing HLA-DR and CD38 at the time of the peak response identified gene modules related to cell cycle regulation and DNA repair that correlated with the contraction phase of the T cell response and consequently the generation of long-lived memory cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE86330 | GEO | 2016/09/12

REPOSITORIES: GEO

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