Genomics

Dataset Information

44

Transcriptomic profiling of dorsal root ganglia of transgenic sickle and control mouse models for studying genetic signatures of pain in sickle cell disease


ABSTRACT: We sequenced mRNA from the dorsal root ganglion (DRG) of transgenic mouse models of sickle cell disease (SCD) and their transgenic controls. Each genotype (strains) were divided into two age groups and each age groups were subjected to two treatment conditions (each simulating acute and chronic pain respectively). Each of these 8 groups had 6 male mice (except one group had 7 mice) resulting into a total of 49 samples. The goal of mRNA sequencing of these samples is to identify genetic signatures associated with transition from acute to chronic pain in SCD. Overall design: Examination of mRNA levels from dorsal root ganglion of transgenic mouse models of sickle cell disease and littermate controls under two dffiferent age groups and two different treatment conditions to find genetic targets that underly SCD pain and transition from acute to chronic pain.

INSTRUMENT(S): Illumina HiSeq 2000 (Mus musculus)

SUBMITTER: Kalpna Gupta 

PROVIDER: GSE86418 | GEO | 2017-04-05

SECONDARY ACCESSION(S): PRJNA341718

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
GSE86418_FPKM_Values_all_samples.xlsx Xlsx
GSE86418_Raw_Read_Counts_all_samples.xlsx Xlsx
Items per page:
1 - 2 of 2

Similar Datasets

2017-01-01 | S-EPMC5749120 | BioStudies
2017-01-01 | S-EPMC5709786 | BioStudies
2017-01-01 | S-EPMC6142592 | BioStudies
2018-01-01 | S-EPMC6317856 | BioStudies
2020-01-01 | S-EPMC7485466 | BioStudies
2014-01-01 | S-EPMC4250326 | BioStudies
2018-01-01 | S-EPMC6087885 | BioStudies
2020-01-01 | S-EPMC7742995 | BioStudies
2019-01-01 | S-EPMC6786911 | BioStudies
1000-01-01 | S-EPMC6142608 | BioStudies