Transcriptomics

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Molecular signature for anastasis, recovery from the brink of apoptotic cell death


ABSTRACT: Cells can survive effector caspase (caspase 3/7) activation in response to transient apoptotic stimuli, a process named anastasis. To characterize the molecular events that occur during anastasis, we performed whole transcriptome RNA sequencing of untreated, apoptotic, and recovering cells. We found that anastasis is an active, two-stage program with unique transcriptional profiles in each stage. We also identified 10 genes that specific to the early stage of anastasis.

ORGANISM(S): Homo sapiens

PROVIDER: GSE86480 | GEO | 2017/07/31

SECONDARY ACCESSION(S): PRJNA342034

REPOSITORIES: GEO

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