Genomics

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Whole genome microarray analysis of C. elegans rrf-3 and eri-1 mutants


ABSTRACT: RRF-3 and ERI-1 are first identified proteins required for accumulation of at least some endogenous secondary siRNAs in C.elegans. Genome wide gene expression analysis was performed on L4 stage rrf-3 and eri-1 mutant C. elegans to study effects caused by loss of these proteins. Mutant rrf-3 and eri-1 strains exhibited similar expression patterns when compared to N2 wild type, while 72 transcripts were found to be co-overexpressed and 4 transcripts co-underexpressed (> 2-fold, p< 0.05). Ontology analysis indicated many of the gene products were associated with protein phosphorylation and sperm function. These results provide additional support for the hypothesis that RRF-3 and ERI-1 act together in a siRNA pathway and may indicate biological processes that are related to endo-siRNAs. Keywords: Mutant vs. wild type -comparison

ORGANISM(S): Caenorhabditis elegans

PROVIDER: GSE8659 | GEO | 2007/10/19

SECONDARY ACCESSION(S): PRJNA101859

REPOSITORIES: GEO

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