Genomics

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Panton-Valentine Leukocidin Does Not Impact Virulence of Community-associated MRSA


ABSTRACT: Panton-valentine leukocidin (PVL) has been linked to worldwide emergence of community-associated methicillin resistant Staphylococcus aureus (CA-MRSA) -- its role in virulence in unclear. Here we show that PVL had no effect on global gene expression of prominent CA-MRSA strains nor did it affect bacterial clearance from lungs, spleen and kidneys in a highly discriminatory rabbit bacteremia model. These findings negate a large body of epidemiological research that implicated PVL in CA-MRSA virulence. Keywords: mutant vs wild type in 2 different growth phases grown in 2 different medias

ORGANISM(S): Rickettsia rickettsii Staphylococcus epidermidis RP62A Yersinia pestis Coxiella burnetii RSA 493 Granulibacter bethesdensis Staphylococcus epidermidis ATCC 12228 Chlamydia muridarum Chlamydia trachomatis D/UW-3/CX Chlamydia trachomatis Staphylococcus haemolyticus JCSC1435 Borreliella burgdorferi B31 Streptococcus pyogenes Staphylococcus aureus Chlamydia pneumoniae AR39 Borreliella burgdorferi Staphylococcus aureus subsp. aureus MW2 Coxiella burnetii Chlamydia caviae GPIC

PROVIDER: GSE8677 | GEO | 2008/09/12

SECONDARY ACCESSION(S): PRJNA101893

REPOSITORIES: GEO

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