Genomics

Dataset Information

167

Epigenetic inflexibility of exhausted T cells limits durability of reinvigoration by PD-1 blockade


ABSTRACT: Upon PD-1 pathway blockade,the epigenetic landscape of exhausted cells was only minimally remodeled consistent with lineage commitment and re-exhaustion of these cells over time. Overall design: Epigenetic profiling of Exhausted T cells & examinaton of epigenetic changes associated with PD-pathway blockade by ATAC-seq using the mouse model of chronic infection with lymphocytic choriomeningitis virus (LCMV)

INSTRUMENT(S): Illumina NextSeq 500 (Mus musculus)

SUBMITTER: E JOHN WHERRY 

PROVIDER: GSE86797 | GEO | 2016-10-31

SECONDARY ACCESSION(S): PRJNA342526

REPOSITORIES: GEO

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Publications


Blocking Programmed Death-1 (PD-1) can reinvigorate exhausted CD8 T cells (TEX) and improve control of chronic infections and cancer. However, whether blocking PD-1 can reprogram TEX into durable memory T cells (TMEM) is unclear. We found that reinvigoration of TEX in mice by PD-L1 blockade caused minimal memory development. After blockade, reinvigorated TEX became reexhausted if antigen concentration remained high and failed to become TMEM upon antigen clearance. TEX acquired an epigenetic prof  ...[more]

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