Genomics

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FACS-array profiling in retinal endothelial cells from living mouse retinas without pericyte coverage


ABSTRACT: Pericytes confer vascular stability in the retina, and the loss of pericytes can cause the blood-retina barrier breakdown seen in diabetic retinopathy. To identify endothelial-specific genes expressed in pericyte-deprived retinal vessels, we purified genetically labeled endothelial cells from Tie2-GFP transgenic mice treated with neutralizing antibody against PDGFRb (APB5) and performed gene expression profiling using DNA microarray. To find out endothelial-specific genes associated with the loss of pericyte coverage, the comparison of microarray data was carried out between retinal endothelial cells (data from GSE27238) and APB5-treated retinal endothelial cells.

ORGANISM(S): Mus musculus

PROVIDER: GSE86819 | GEO | 2017/01/01

SECONDARY ACCESSION(S): PRJNA342618

REPOSITORIES: GEO

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