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Genome-wide occupancy of LSD1 in differentiating C2C12 myoblasts.

ABSTRACT: ChIP-seq analysis of LSD1 in C2C12 cells. We found that LSD1 directly regulates the expression of fiber and metabolism genes during myogenesis. Results provide insight into the molecular mechanisms of myogenesis.

ORGANISM(S): Mus musculus

PROVIDER: GSE86856 | GEO | 2018/03/19

REPOSITORIES: GEO

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Genome-wide occupancy of LSD1 in differentiating and differentiated C2C12 myoblasts.

Project description:ChIP-seq analysis of LSD1 in C2C12 cells. We found that LSD1 directly regulates the expression of fiber and metabolism genes during myogenesis. Results provide insight into the metabolic prgramming mechanisms of myogenesis.

2018-03-19 | GSE109846 | GEO

Effect of LSD1 knockdown on differentiating C2C12 myoblasts

Project description:Analysis of differentiating LSD1-KD C2C12 myoblasts. We found LSD1 is an important regulator of oxidative phenotypes in skeletal muscle cells. Results provide insight into the molecular mechanisms underlying roles of LSD1 in myocytes.

2018-03-19 | GSE109839 | GEO

Effect of LSD1 inhibition on differentiating C2C12 myoblasts

Project description:Analysis of differentiating C2C12 myoblasts treated with two LSD1 specific inhibitors. We found LSD1 is an important regulator of oxidative phenotypes in skeletal muscle cells. Results provide insight into the molecular mechanisms underlying roles of LSD1 in myocytes.

2018-03-19 | GSE86524 | GEO

Genome-wide distribution of methylated H3K4 in LSD1-inhibited C2C12 myoblasts.

Project description:ChIP-seq analysis of methylated H3K4 in LSD1-inhibited C2C12 cells. We found that LSD1 widely regulates the methylation levels of H3K4. Results provide insight into the molecular mechanisms of regulation of histone modification in myogenesis.

2018-03-19 | GSE109845 | GEO

Effect of LSD1 knockdown on differentiating C2C12 myoblasts

Project description:Effect of LSD1 knockdown on differentiating C2C12 myoblasts

| PRJNA432163 | ENA

Genome-wide occupancy of LSD1 in differentiating and differentiated C2C12 myoblasts.

Project description:Genome-wide occupancy of LSD1 in differentiating and differentiated C2C12 myoblasts.

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Determination of Lsd1 function in C2C12 myoblast cells by global transcriptome analysis

Project description:First, we aimed to identify genes whose transcript levels change at the onset of myogenic versus adipogenic differentiation of muscle precursors. We therefore compared RNA-seq results obtained from C2C12 cells differentiated for 1 day in myogenic and adipogenic medium. Out of these genes, we wanted to determine those whose expression was affected by altered Lsd1 levels. To this end, we performed RNA-seq in C2C12 cells upon LSD1 overexpression and Lsd1 knock-down in adipogenic medium and compared them to corresponding control cells.

2017-12-15 | GSE98133 | GEO

Comprehensive analysis of the proteome, phosphoproteome and N-linked sialylated glycoproteome of C2C12 myoblasts

Project description:C2C12 myoblast is a model that has been used extensively to study the process of skeletal muscle differentiation. Proteomics has advanced our understanding of skeletal muscle biology and the process of myogenesis. However, there is still no deep coverage of C2C12 myoblast proteome, which is important for the understanding of key drivers for the differentiation of skeletal muscle cells. Here, we conducted a multi-dimensional proteome profiling with TiSH strategy to get a comprehensive analysis of proteome, phosphoproteome and N-linked sialylated glycoproteome of C2C12 myoblasts. A total of 8313 protein groups were identified in C2C12 myoblasts, including 7827 protein groups from non-modified peptides, 3803 phosphoproteins and 977 formerly N-linked sialylated glycoproteins.

2020-11-27 | PXD011334 | Pride

Genome-wide distribution of methylated H3K4 in LSD1-inhibited C2C12 myoblasts.

Project description:Genome-wide distribution of methylated H3K4 in LSD1-inhibited C2C12 myoblasts.

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Genome-wide Lsd1 chromatin occupancy in myoblast C2C12 cells by chromatin immunoprecipitation using an Lsd1 antibody followed by massive parallel sequencing

Project description:Purpose: The aim of this study is to identify the Lsd1 genome binding profile in myoblast C2C12 cells during myogenic and adipogenic differentiation. ChIP-seq libraries were prepared, sequenced using the standard Illumina protocol (HiSeq2000, single read, 50 bp v3), and mapped to the mouse mm10 reference genome by Bowtie. Data were further analyzed using the peak finding algorithm MACS 1.4.2. Homer software was used to annotate peaks, and all peaks with false discovery rate less than 1 % were included.

2017-12-15 | GSE98134 | GEO

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