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Gene expression in liver and hypothalamus from ob/ob mice treated with γ-oryzanol-encapsulated nanoparticles

ABSTRACT: Brown rice-specific bioactive substance, γ-oryzanol ameliorates fuel dysmetaborism, but it is hardly absorbed form the intestine. To increase the efficiency of its absorption, we therefore challenged to encapsulate γ-oryzanol in polymer poly (DL-lactide-co-glycolide) (PLGA) nanoparticles. We assessed the metabolically-beneficial impact of PLGA-encapusulated γ-oryzanol on fuel dyshomeostasis in genetically obese-diabetic ob/ob mice.

ORGANISM(S): Mus musculus

PROVIDER: GSE86858 | GEO | 2019/09/13

REPOSITORIES: GEO

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