Protein Kinase CK2 Controls the Fate Between Th17 Cell and Regulatory T Cell Differentiation

ABSTRACT: We report that CK2 inhibition with CX-4945 broadly suppresses Th17-associated effector and metabolic gene expression. CD4+ T cells were cultured in IL-6, IL-23 and TGFb1 for 72 h, in the absence of presence of 2 mM CX-4945, RNA-seq was performed and gene expression compared between the control and treatment groups.

ORGANISM(S): Mus musculus

PROVIDER: GSE86976 | GEO | 2017/05/05

SECONDARY ACCESSION(S): PRJNA343123

REPOSITORIES: GEO