Dataset Information


MRNA Next Generation Sequencing of long-lived C. elegans mutants lacking the replication-independent histone variant H3.3

ABSTRACT: The aim of this stuy was to investigate the effect of H3.3 deficiency on gene transcription in both a wild-type and a long-lived mutant context in C. elegans. Overall design: Next Generation mRNA sequencing was performed on 5 biological replicates of late L4 wild-type, his-72(tm2066); his-71(ok2289), daf-2(e1370), daf-2(e1370); his-72(tm2066); his-71(ok2289), nuo-6(qm200) and nuo-6(qm200); his-72(tm2066); his-71(ok2289).

INSTRUMENT(S): Illumina HiSeq 2500 (Caenorhabditis elegans)

SUBMITTER: Daniele Bano 

PROVIDER: GSE87078 | GEO | 2016-10-01



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Replication-Independent Histone Variant H3.3 Controls Animal Lifespan through the Regulation of Pro-longevity Transcriptional Programs.

Piazzesi Antonia A   Papić Dražen D   Bertan Fabio F   Salomoni Paolo P   Nicotera Pierluigi P   Bano Daniele D  

Cell reports 20161001 4

Chromatin structure orchestrates the accessibility to the genetic material. Replication-independent histone variants control transcriptional plasticity in postmitotic cells. The life-long accumulation of these histones has been described, yet the implications on organismal aging remain elusive. Here, we study the importance of the histone variant H3.3 in Caenorhabditis elegans longevity pathways. We show that H3.3-deficient nematodes have negligible lifespan differences compared to wild-type ani  ...[more]

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