Transcriptomics,Genomics

Dataset Information

46

Omeprazole regulate gastric cancer microenvironment by regulate exosomes associated miRNA


ABSTRACT: Exosomal miRNAs have emerged as microcommunicators of pathologic conditions including cancer where they educate the tumor microenvironment in favor of metastasis. We purified exosomes from the medium of SCG-7901 cells which was treated by 80ug/ml omeprazole 24h and was analysed by Aglient human microarray. Overall design: SGC-7901 cells was treated with omeprazole at 80ug/ml for 24h, and PBS was used as control. And the medium of SGC-7901 cells were collected and the exosomes were isolated by ExoQuick-TC exosome precipitation solution. Then the miRNA involved in exosomes was isolated by the total RNA purification Kit.Next the miRNA was analysised by microarry.

INSTRUMENT(S): Agilent-046064 Unrestricted_Human_miRNA_V19.0_Microarray (Probe Name version)

SUBMITTER: Xu-wen Guan  

PROVIDER: GSE87152 | GEO | 2018-01-01

SECONDARY ACCESSION(S): PRJNA343725

REPOSITORIES: GEO

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