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Gene expression profile of peri-implantation uteri treated with LPA3 receptor agonist

ABSTRACT: To investigate gene expression changes induced by Lysophosphatidic acid receptor 3 (LPA3) activation in peri-implantation uteri, we performed microarray analysis in LPA3 agonist (T13)-injected pseudopregnant uteri. On 3.5 dpc, pseudopregnant mice were subjected with intrautero-injection of vehicle (0.01% BSA-PBS) or T13 and then uteri were dissected 24-36 hr after the injection. We found that several thousand genes were up- or down-regulated by T13 injection. Interestingly, well-known decidual markers such as Bmp2 and Wnt4 were dramatically induced by T13, which we certificated in quantitive RT-PCR.

ORGANISM(S): Mus musculus

PROVIDER: GSE87161 | GEO | 2017/05/31

SECONDARY ACCESSION(S): PRJNA343767

REPOSITORIES: GEO

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