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The anti-leukemic effect of R-2HG depends on its acting as an m6A mRNA modifier-RNA Seq-PBS / R-2HG treatment

ABSTRACT: RNA-seq from R-2HG sensitive leukemia cells treated with R-2HG or PBS.

ORGANISM(S): Homo sapiens

PROVIDER: GSE87189 | GEO | 2017/12/14

SECONDARY ACCESSION(S): PRJNA343812

REPOSITORIES: GEO

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The anti-leukemic effect of R-2HG depends on its acting as an m6A mRNA modifier-M6A Seq

Project description:m6A-seq in NOMO-1, MA9.3RAS and MA9.3ITD cells with or without R-2HG treatment.

2017-12-14 | GSE87190 | GEO

The anti-leukemic effect of R-2HG depends on its acting as an m6A mRNA modifier-RNA Seq-Resistant, sensitive and healthy control

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RNA-seq analysis after MIR4435-2HG knockdown in HemECs

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2023-10-29 | GSE236203 | GEO

The effect of 2HG level on transcriptome at different stages of male mouse meiosis

Project description:We found that L2-hydroxyglutarate (2HG) level is 15 times higher in pachytene-diplotene (PD) stage as compared to leptotene-zygotene (LZ) stage. Since 2HG shows epigenetic effects we asked if the addition of 2HG to LZ cells or the decrease of 2HG level in PD cells will cause changes in gene expression.

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Transcriptome of human endothelial cells treated with R-2HG or S-2HG

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HNF4A-induced lncRNA MIR194-2HG derived miR-194 and miR-192 coordinatively inhibit gastric cancer progression by targeting BTF3L4

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