Genomics

Dataset Information

45

Genome variation profiling of A204 parental and acquired-resistance cells treated with Pazopanib, Dasatinib and Sunitinib


ABSTRACT: Malignant rhadboid tumors (MRTs) are lethal paediatric cancers characterised by a deficiency in the SWI/SNF subunit SMARCB1. Here we employ an integrated molecular profiling and chemical biology approach to demonstrate that the receptor tyrosine kinases (RTKs) PDGFRα and FGFR1 are coactivated in MRT cells and that dual blockade of these receptors has synergistic efficacy. Genome variation profiling of A204 parental and acquired resistance cell line Overall design: Genome variation profiling of 4 cell lines, parental A204, A204 Dasatinib resistant, A204 Pazopanib resistant and A204 Sunitinib resistant

INSTRUMENT(S): Reis-Filho Human 32K BAC

SUBMITTER: Aik Choon Tan  

PROVIDER: GSE87208 | GEO | 2016-09-23

SECONDARY ACCESSION(S): PRJNA343883

REPOSITORIES: GEO

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Publications


Subunits of the SWI/SNF chromatin remodeling complex are mutated in a significant proportion of human cancers. Malignant rhabdoid tumors (MRTs) are lethal pediatric cancers characterized by a deficiency in the SWI/SNF subunit SMARCB1. Here, we employ an integrated molecular profiling and chemical biology approach to demonstrate that the receptor tyrosine kinases (RTKs) PDGFRα and FGFR1 are coactivated in MRT cells and that dual blockade of these receptors has synergistic efficacy. Inhibitor comb  ...[more]

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