Genomics

Dataset Information

35

Complete atrio-ventricular canal defects in mouse hearts lacking G-protein receptor kinases


ABSTRACT: Combined ablation of all 3 cardiac-expressed GRKs in the developing mouse heart impaired Hedgehog/Smoothened and GATA signaling, recapitulating heart abnormalities of human Complete Atrioventricular Septal Defect. Overall design: Cardiac transcriptomes from mouse E13.5 hearts (8 wt, 8 haploinsufficient GRK2+/-GRK5-/-GRK6-/- and 7 GRK-triple knockout GRK2-/-GRK5-/-GRK6-/-) were generated via Illumina RiboZeroGold rRNA depletion and subsequent single-end 50 nt sequencing on Illumina HiSeq 2500

INSTRUMENT(S): Illumina HiSeq 2500 (Mus musculus)

SUBMITTER: Scot J Matkovich  

PROVIDER: GSE87321 | GEO | 2017-09-30

SECONDARY ACCESSION(S): PRJNA344339

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
GSE87321_GRKTKO_project_FPKM.txt.gz Txt
GSE87321_GRKTKO_project_HTSeq.txt.gz Txt
GSE87321_genes+EnsemblGRCm38MT+Cre_individ-exons-GRK256Nkx2-5.gtf.gz Other
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