Dataset Information


Treg cell gene expression signature in B16 melanoma

ABSTRACT: Gene expression signature of Treg cells in B16 melanoma was measured and compared to B16-infiltrating CD4+ Tconv cells and CD8+ T cells as well as splenic Treg cells, CD4+ Tconv cells and CD8+ T cells. Overall design: We isolated regulatory and conventional CD4+ T cells as well as CD8+ T cells from B16 melanoma and spleen of mice. Cells were isolated, pooled and target cells were purified by FACS. RNA was extracted and gene expression measured.

INSTRUMENT(S): Illumina MouseWG-6 v2.0 R2 expression beadchip

SUBMITTER: Markus Feuerer  

PROVIDER: GSE87335 | GEO | 2016-10-31



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Tryptophan metabolism is a key process that shapes the immunosuppressive tumor microenvironment. The two rate-limiting enzymes that mediate tryptophan depletion, indoleamine-2,3-dioxygenase (IDO) and tryptophan-2,3-dioxygenase (TDO), have moved into the focus of research and inhibitors targeting IDO and TDO have entered clinical trials. Local tryptophan depletion is generally viewed as the crucial immunosuppressive mechanism. In T cells, the kinase general control non-derepressible 2 (GCN2) has  ...[more]

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