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Array-CGH screening of pediatric low-grade astrocytomas (n=66)

ABSTRACT: DNA copy-number profiling of 66 astrocytomas of WHO °I or °II Keywords: Genetic modification

ORGANISM(S): Homo sapiens

PROVIDER: GSE8737 | GEO | 2007/08/10

SECONDARY ACCESSION(S): PRJNA102001

REPOSITORIES: GEO

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Array-CGH screening of pediatric low-grade astrocytomas (n=66)

Project description:DNA copy-number profiling of 66 astrocytomas of WHO °I or °II Comparison of tumor DNA (tumor) versus control DNA (pool of lymphocyte DNA from 10 healthy donors). Whole-genome screening for DNA copy-number aberrations using array-based comparative genomic hybridization (aCGH). Tumor DNA labeled in Cy3 and control DNA labeled in Cy5.

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Affymetrix SNP array data for low-grade astrocytoma samples

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Adult grade II astrocytomas are genetically distinct from their pediatric counterparts, and display a more stem cell-like expression pattern linked with more aggressive behaviour

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Transcription profiling of human grade II astrocytic tumor (astrocytomas) vs grade IV tumors (glioblastoma)

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Adult grade II astrocytomas are genetically distinct from their pediatric counterparts, and display a more stem cell-like expression pattern linked with more aggressive behaviour

Project description:We have used microarray comparative genomic hybridization (aCGH) at 1Mb resolution to study copy number changes in a series of WHO Grade II Astrocytomas (n=21). We have used Illumina arrays to study genome-wide expression patterns in a series of WHO Grade II Astrocytomas (n=10). Keywords: Array Comparative Genomic Hybridization (aCGH), Expression microarray [aCGH]: Single hybridization per case. 21 astrocytomas WHO grade II were analyzed. Target (tumor) labelled with Cy5 and reference with Cy3. Mixture of 20 normal male or female genomic DNA was used in sex-mismatched hybridization. [mRNA]: Single hybridization per case. 10 astrocytomas WHO grade II were analyzed (5 adult, 5 pediatric)

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