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Hyperglycemic Memory – New insights into a thought to be known topic

ABSTRACT: Hyperglycemic memory is part of the pathogenesis of diabetic retinopathy. We established a novel mouse model of intermediate-term hyperglycemic memory and demonstrated that changes in gene expression and microvascular damage in the neurovascular unit of the diabetic retina persist after euglycemic reentry, indicating memory. Using microarrays and functional annotation clustering of full genome expression data, genes meeting the criteria for hyperglycemic memory were attributed to the cytoskeletal and nuclear compartments of cells of the neurovascular unit.

ORGANISM(S): Mus musculus

PROVIDER: GSE87433 | GEO | 2017/02/01

SECONDARY ACCESSION(S): PRJNA344758

REPOSITORIES: GEO

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