Transcriptomics,Genomics

Dataset Information

43

Expression data from human breast cancer cell MCF-7 and human gastric cancer cell SGC-7901


ABSTRACT: Piper longum L. is a well-known traditional antihyperlipidemic medicine,and it has ability to inhibit proliferation of cancer cells,potassium piperate (GBK) maybe have the same effect. We used microarrays to detail the global programme of gene expression underlying cellularisation and identified distinct classes of up-regulated and down-regulated genes during this process. Overall design: treat and untreat with GBK on MCF-7 and SGC-7901 for RNA extraction and hybridization on Affymetrix microarrays. And then analysis the result to compare the express level between two cells that treat or untreat with GBK.

INSTRUMENT(S): [PrimeView] Affymetrix Human Gene Expression Array

SUBMITTER: xuemin Cao  

PROVIDER: GSE87440 | GEO | 2017-09-18

SECONDARY ACCESSION(S): PRJNA344773

REPOSITORIES: GEO

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Publications

The synthetic antihyperlipidemic drug potassium piperate selectively kills breast cancer cells through inhibiting G1-S-phase transition and inducing apoptosis.

Fan Lifei L   Cao Xuemin X   Yan Huijuan H   Wang Qian Q   Tian Xiaoxia X   Zhang Lan L   He Xiaoyan X   Borjihan Gereltu G   Morigen  

Oncotarget 20170701 29


Piper longum L. is a well-known traditional antihyperlipidemic medicine in China, containing medicinal constituents of piperine, pipernonaline and piperlonguminine in its fruit. However, the antitumor properties of these constituents have not yet been studied. We found that potassium piperate (GBK), a derivative of piperine, inhibited proliferation of cancer cells. GBK selectively inhibited the G1-S-phase transition in breast cancer cells and the G1 arrest was correlated with induction of p27 ex  ...[more]

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