Genomics

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The EMT-activator Zeb1 is crucial for cellular plasticity and drives metastasis in pancreatic cancer


ABSTRACT: Depletion of Zeb1 in a KPC-model for pancreatic cancer affected strongly the formation of precursor lesions, tumour grading, invasion and notably metastasis during PDAC progression. In this context, EMT is important for metastasis, but there is variability and specificity (and not redundancy) in the role and function of different EMT-inducing transcription factors.

ORGANISM(S): Mus musculus

PROVIDER: GSE87472 | GEO | 2017/03/16

SECONDARY ACCESSION(S): PRJNA344877

REPOSITORIES: GEO

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