Dataset Information


Mapping of H2A.Z nucleosomes in CD4/CD8 DP thymocytes

ABSTRACT: H2A.Z ChIP-Seq in CD4/CD8 DP thymocytes Overall design: Examination of H2A.Z nucleosomes in CD4/CD8 DP thymocytes

INSTRUMENT(S): Illumina Genome Analyzer II (Mus musculus)

SUBMITTER: Pierre Daniel Cauchy  

PROVIDER: GSE87529 | GEO | 2017-02-07



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Two possible modes of pioneering associated with combinations of H2A.Z and p300/CBP at nucleosome-occupied enhancers.

Cauchy Pierre P   Koch Frederic F   Andrau Jean-Christophe JC  

Transcription 20170213 3

Pioneer transcription factors are defined by their ability to bind nucleosome-occupied regions. Here, we discuss the properties of nucleosomes bound by pioneers at enhancer regions. We describe how select pioneers bind nucleosome-occupied or -depleted enhancer sites. Importantly, by revisiting and expanding existing data sets, we show differential H2A.Z and p300/CBP association at bound enhancers, highlighting two possible pioneering modes. ...[more]

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