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Comparative transcriptome analysis of Brucella suis 1330 wild-type and DregA mutant

ABSTRACT: Investigation of whole genome gene expression level changes in a B. suis 1330 regA mutant, compared to the wild-type strain. The two-component system RegBA of Brucella suis plays a central role in the control of respiratory systems adapted to oxygen deficiency. The mutant strain is affected in long-term persistence in vitro (this study) and in chronic infection in vivo (Abdou, E et al. 2013, Infect.Immun. 81: 2053-61). Using an original “in vitro model of persistence”, we compare large-scale transcriptome of the wild-type and ∆regA strains to identify the RegA-regulon potentially involved in the set-up of the persistence state.

ORGANISM(S): Brucella suis 1330 Brucella suis

PROVIDER: GSE87538 | GEO | 2017/06/26

SECONDARY ACCESSION(S): PRJNA345140

REPOSITORIES: GEO

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