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Gene expression profile analysis of CD8+ T cells isolated from splenic red and white pulp upon LCMV infection

ABSTRACT: We performed RNAseq analysis on CD8+ T cells isolated from splenic white and red pulp upon lymphocytic choriomeningitis virus-Arm infection to understand how cell function and fate are determined. Analyses of transcriptional profiles revealed that decisions for gene expression patterns to become a memory cell were established during the early contraction phase by 11 days post infection (dpi) and their expression remained constant throughout the T cell development. This study may have important implication for development of efficacious vaccines.

ORGANISM(S): Mus musculus

PROVIDER: GSE87561 | GEO | 2016/11/21

SECONDARY ACCESSION(S): PRJNA345195

REPOSITORIES: GEO

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