Transcriptomics,Genomics

Dataset Information

61

Gene expression of L3 and L5 pyramidal neurons in the DLPFC comparing schizophrenia from bipolar major depressive disorders and unaffected subjects.


ABSTRACT: Impairments in certain cognitive processes (e.g., working memory) are typically most pronounced in schizophrenia (SZ), intermediate in bipolar disorder (BP) and least in major depressive disorder (MDD). Given that working memory depends, in part, on neural circuitry that includes pyramidal neurons in layer 3 (L3) and layer 5 (L5) of the dorsolateral prefrontal cortex (DLPFC), we sought to determine if transcriptome alterations in these neurons were shared or distinctive for each diagnosis. Overall design: We collected brain specimens (n=76) with SZ (n=19; 6 had schizoaffective disorder), BP (n=19; all had bipolar 1 disorder) or MDD (n=19) and UC subjects (n=19) which were matched as tetrads for sex and as closely as possible for age. Each subject has 2 technique replicates.

INSTRUMENT(S): [HG-U219] Affymetrix Human Genome U219 Array

SUBMITTER: David Lewis  

PROVIDER: GSE87610 | GEO | 2017-04-04

SECONDARY ACCESSION(S): PRJNA345378

REPOSITORIES: GEO

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Publications

Transcriptome Alterations in Prefrontal Pyramidal Cells Distinguish Schizophrenia From Bipolar and Major Depressive Disorders.

Arion Dominique D   Huo Zhiguang Z   Enwright John F JF   Corradi John P JP   Tseng George G   Lewis David A DA  

Biological psychiatry 20170404 8


BACKGROUND:Impairments in certain cognitive processes (e.g., working memory) are typically most pronounced in schizophrenia (SZ), intermediate in bipolar disorder, and least in major depressive disorder. Given that working memory depends, in part, on neural circuitry that includes pyramidal cells in layer 3 (L3) and layer 5 (L5) of the dorsolateral prefrontal cortex (DLPFC), we sought to determine if transcriptome alterations in these neurons were shared or distinctive for each diagnosis. METHOD  ...[more]

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