Metabolic pathway activation distinguish transcriptional signatures of CD8+ T cells from HIV-1 elite controllers

ABSTRACT: Elite controllers (EC), defined as persons maintaining undetectable levels of HIV-1 replication in the absence of antiretroviral therapy, represent living evidence that sustained, natural control of HIV-1 is possible, at least in relatively rare instances. Understanding the complex immunologic and virologic characteristics of these specific patients holds promise for inducing drug-free control of HIV-1 in broader populations of HIV-1 infected patients.

ORGANISM(S): Homo sapiens

PROVIDER: GSE87620 | GEO | 2018/08/01

REPOSITORIES: GEO