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VRTN Regulates the Number of Thoracic Vertebrae During Vertebrate Development

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Sus scrofa Homo sapiens

PROVIDER: GSE87776 | GEO | 2019/10/09

REPOSITORIES: GEO

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VRTN Regulates the Number of Thoracic Vertebrae During Vertebrate Development [ChIP-seq]

Project description:The number of vertebrae is precisely defined in almost all vertebrate species, but varies considerably in pigs, making this animal an excellent model for studying the mechanisms that control vertebral number. Vertnin (VRTN) variants have been associated with thoracic vertebral number (TVN) in pigs. However, the causal relation between VRTN and TVN remains to be established, and the role of VRTN in modulating TVN is not yet known. Here, we demonstrate that VRTN is one of the genes responsible for determining TVN. We show that VRTN is a DNA-binding transcription factor, which is essential for the formation of thoracic vertebrae during early embryogenesis as VRTN-null mice showed embryonic lethality at the later thoracic somite stages and had fewer somites than their wild-type and heterozygous littermates. We also show that VRTN causative variants increase Notch signaling in pig embryos, suggesting that VRTN controls segment number by altering the pace of somatic segmentation. These findings advance our understanding of the role of VRTN in the formation of thoracic vertebrae and reveal new aspects of somite developmental biology.

2019-10-09 | GSE87774 | GEO

VRTN Regulates the Number of Thoracic Vertebrae During Vertebrate Development [RNA-seq]

2019-10-09 | GSE87775 | GEO

VRTN Regulates the Number of Thoracic Vertebrae During Vertebrate Development

Project description:VRTN Regulates the Number of Thoracic Vertebrae During Vertebrate Development

| PRJNA347516 | ENA