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Regulatory Role of SLFN5 in Type I Interferon Signaling

ABSTRACT: We provide evidence that a member of the IFN-regulated member of the Schlafen (SLFN) family of proteins, SLFN5, promotes the malignant phenotype in glioblastoma multiforme (GBM). Our studies demonstrate that SLFN5 negatively regulates expression of key interferon stimulated genes (ISGs) that mediate important biological functions, including anti-viral and antineoplastic responses.

ORGANISM(S): Homo sapiens

PROVIDER: GSE88771 | GEO | 2017/01/31

SECONDARY ACCESSION(S): PRJNA348531

REPOSITORIES: GEO

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