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High fat diet-induced changes of mouse hepatic transcription and enhancer activity can be reversed by subsequent weight loss.

ABSTRACT: In this setup we have used RNA-seq, DHS-seq, and H3K27ac ChIP-seq to identify changes in transcription, chromatin landscape and enhancer activity in livers of mice fed a high fat diet (HFD) and mice returned from HFD to Chow.

ORGANISM(S): Mus musculus

PROVIDER: GSE88818 | GEO | 2017/01/11

SECONDARY ACCESSION(S): PRJNA348732

REPOSITORIES: GEO

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High fat diet-induced changes of mouse hepatic transcription and enhancer activity can be reversed by subsequent weight loss

Project description:In this setup we have used RNA-seq, DHS-seq, and H3K27ac ChIP-seq to identify changes in transcription, chromatin landscape and enhancer activity in livers of mice fed a high fat diet (HFD) and mice returned from HFD to Chow.

2016-12-15 | GSE87565 | GEO

Gene expression in the liver, effect of maternal high-fat diet during or prior to pregnancy

2013-06-18 | GSE48014 | GEO

Combined metabolomic and transcriptomic profiling approaches reveal the cardiac response to high-fat diet

Project description:Purpose: Observing the response of the heart to dietary interventation at the metabolomic and transcriptomic level may have relevance for cardiovascular diseases Methods: RNA Seq of 12 week old WT male mice on chow or HFD and WT female mice on Chow or HFD; RNA was extracted and reverse-transcribed after polyA selection to complementary DNA for sequencing on an Illumina NovaSeq platform Results: RNAseq from heart tissue revealed significant differences in expression of 292 mRNA, with an FDR <0.05. PCA showed that there were significant sex differences in chow-fed mice. It also separated HFD-fed vs. Chow-fed samples for both male and female mice. Conclusions: This work reveals the response of a vital organ to dietary intervention at both metabolomic and transcriptomic levels, which is a fundamental question in physiology that may have relevance for cardiovascular diseases. This work also reveals significant sex differences in cardiac metabolites and gene expression.

2022-04-11 | GSE198546 | GEO

Gene expression in the liver, effect of maternal high-fat diet during or prior to pregnancy

Project description:The present study aimed to examine the effect of high-fat diet prior to pregnancy on the liver of mouse offspring. Female C57BL/6J mice were fed a normal chow (15.2% fat by energy) (CTR and CTR-PP groups) or a high-fat chow (31.2% fat by energy) (HFD and HFD-PP groups) for 3−4 weeks and then mated with male C57BL/6J mice fed normal chow. Some mothers continued on the same diet until pups reached 21 days of age (CTR and HFD), and others were fed the different chows from gestational day 0 (CTR-PP and HFD-PP) to determine the effects of a high-fat diet during the pre-pregnancy period in HFD-PP/CTR and HFD/CTR-PP comparisons. RNA sample was taken from liver of 3-week-old mouse prenatally received high-fat diet prior to pregnancy, during pregnancy and lactation, or through prior to and during pregnancy and lactation, while control RNA was taken from control counterpart prenatally received normal diet alone. Comparisons among groups were made by one-color method with normalized data from Cy3 channels for data analysis.

2013-06-18 | E-GEOD-48014 | biostudies-arrayexpress

high fat diet feed mice liver sample proteomics

Project description:determine the effect of the high-fat diet on the proteomics profile of liver tissue.Mice were fed with HFD for 16 weeks to establish a NAFLD mouse model. Mice fed with normal chow diet were taken as controls. Five replicate liver samples were collected from each group for proteomics analysis.

2022-06-09 | PXD030727 | Pride

High fat diet-induced changes of mouse hepatic transcription and enhancer activity can be reversed by subsequent weight loss.

Project description: Not available

| S-EPMC5223143 | biostudies-literature

A dietary change to a high fat diet initiates a rapid adaptation of the intestine

Project description:Examine the single cell transcriptional changes during Normal Chow and Acute HFD

2022-11-15 | GSE199776 | GEO

Proteomics of liver from mice fed high fat diet (HFD) or regular chow diet

Project description:Proteomics of liver tissue from mice fed a high fat diet (HFD) or regular chow diet. Data accompany our paper entitled “Dynamic Regulation of N6,2′-O-dimethyladenosine (m6Am) in Obesity” scheduled for publication in Nature Communications, 2021

2021-10-27 | PXD029280 | Pride

Phosphoribotrap-based profiling of activated hypothalamic cells during acute high-fat diet (HFD)-feeding

Project description:To identify novel neurocircuits activated upon short-term HFD feeding, we employed phosphoribotrap-profiling, which allows for the unbiased identification of alterations in neuronal activation via immunoprecipitation of phosphorylated S6 ribosomal protein-tagged ribosomes from hypothalamic extracts of mice exposed to either 3 days of normal chow diet or HFD-feeding. We have analyzed mRNA selectively expressed in hypothalamic cells activated by a either normal chow diet (NCD)-feeding for 3 days or high fat diet (HFD)-feeding for 3 days. 10-week-old male C57/BL6N mice were put either on a normal chow diet or a high fat diet for 3 days. Afterwards, mice were sacrificed by cervical dislocation. The hypothalamus was rapidly dissected using a stainless steel brain matrix and immediately frozen in liquid nitrogen. Hypothalamic tissues were pooled (8 per IP).

2020-04-16 | GSE137737 | GEO

Proteomics analysis of insulin sensitive tissues in high fat diet fed mice

Project description:The popularity of high fat foods in modern society has been associated with epidemic of various metabolic diseases characterized by insulin resistance, the pathology of which involves complex interactions between multiple tissues such as liver, skeletal muscle and white adipose tissue (WAT). To uncover the mechanism by which excessive fat impairs insulin sensitivity, we conducted a multi- tissue study by using TMT-based quantitative proteomics. 3-week-old ICR mice were fed with high fat diet (HFD) for 19 weeks to induce insulin resistance. Liver, skeletal muscle and epididymal fat were collected for proteomics screening. Additionally, PRM was used for validating adipose differential proteins. By comparing tissue-specific protein profiles of HFD mice, multi-tissue regulation of glucose and lipid homeostasis and corresponding underlying mechanisms was systematically investigated and characterized. NC: normal birth weight + chow diet; NH: normal birth weight + high fat diet; LC: low birth weight + chow diet; LH: low birth weight + high fat diet.

2022-01-26 | PXD021046 | Pride

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