Genomics

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Effects of IDH1-R132H on mouse neural stem cells


ABSTRACT: Mouse neural stem cells were generated from conditional knock-in mice. Mutant IDH1 is conditionally expressed following expression of Cre-recombinase. Cre-recombinase was incorporated in vitro via adenoviral-Cre recombinase. Addtionally, adenoviral-GFP was also used to control for effects of adenoviral infection. D-2HG, the metabolic product of IDH1-R132H, was detected in cell lines post-cre transduction

ORGANISM(S): Mus musculus

PROVIDER: GSE88828 | GEO | 2017/08/22

SECONDARY ACCESSION(S): PRJNA348745

REPOSITORIES: GEO

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