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MKL1/2 dependent target genes

ABSTRACT: Megakaryoblastic Leukemia 1 and 2 (MKL1 and 2) are coactivators of the transcription factor Serum Response Factor (SRF). We recently showed that depletion of MKL1 and 2 abolished HCC xenograft growth, associated with oncogene-induced senescence. To identify suitable MKL target genes mediating these effects, we performed microarray analyses using HuH7 hepatocellular carcinoma cells stably expressing shRNA against MKL1/2 (HuH7 MKL1/2 KD). We therefore used a Affymetrix oligonucleotide array and filtered for genes whose expression in HuH7 MKL1/2 KD cells was reduced by a factor of at least 2.5 as compared to control HuH7 cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE88974 | GEO | 2017/01/01

SECONDARY ACCESSION(S): PRJNA349271

REPOSITORIES: GEO

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MKL1 promotes megakaryocytic differentiation in HEL cells

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MKL1 deficiency results in a neutrophil motility defect with impaired actin polymerization and excessive degranulation

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