Genomics

Dataset Information

41

Identification of miRNA, lncRNA and mRNA-associated ceRNA networks and potential biomarker for MELAS with mitochondrial DNA A3243G mutation [sequencing]


ABSTRACT: To elucidate the regulating networks of dysregulated ncRNAs in Mitochondrial myopathy, Encephalopathy, Lactic Acidosis, and Stroke-like episodes (MELAS) with m.A3243G mutation. Overall design: The MELAS sample consisted of a muscle pool from 20 MELAS patients with m.A3243G mutation, and the Control sample consisted of a muscle pool from 20 healthy controls. LncRNA sequencing and miRNA array of muscle pools were performed by the service provider (LC Sciences). The secondary qRT-PCR validation of the most promising miRNAs and lncRNAs using individual samples were from the same group. The findings were all consistent with results from our high-throughput data.

INSTRUMENT(S): Illumina HiSeq 2500 (Homo sapiens)

SUBMITTER: Wei Wang  

PROVIDER: GSE89065 | GEO | 2016-10-23

SECONDARY ACCESSION(S): PRJNA350208

REPOSITORIES: GEO

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Publications

Identification of miRNA, lncRNA and mRNA-associated ceRNA networks and potential biomarker for MELAS with mitochondrial DNA A3243G mutation.

Wang Wei W   Zhuang Qianqian Q   Ji Kunqian K   Wen Bing B   Lin Pengfei P   Zhao Yuying Y   Li Wei W   Yan Chuanzhu C  

Scientific reports 20170131


Researchers in the field of mitochondrial biology are increasingly unveiling of the complex mechanisms between mitochondrial dysfunction and noncoding RNAs (ncRNAs). However, roles of ncRNAs underlying mitochondrial myopathy remain unexplored. The aim of this study was to elucidate the regulating networks of dysregulated ncRNAs in Mitochondrial myopathy, Encephalopathy, Lactic Acidosis, and Stroke-like episodes (MELAS) with mitochondrial DNA (mtDNA) A3243G mutation, which might make contribution  ...[more]

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