Transcriptomics,Genomics

Dataset Information

171

Integrative analysis of translatome and transcriptome of adipocytes


ABSTRACT: To systemically determine the translational control of gene expression in adipose, we performed ribosome profiling and RNA-seq in parallel to depict the translatome and transcriptome changes during primary brown and white adipogenesis, and between brown and white adipose tissue. Overall design: ribosome profiling and mRNA profiling were performed using the same biological material for interscapular brown fat, epididymal white fat, in vitro cultured white and brown preadipocytes and differentiated adipocytes

INSTRUMENT(S): Illumina HiSeq 2500 (Mus musculus)

SUBMITTER: David Reid 

PROVIDER: GSE89108 | GEO | 2017-08-04

SECONDARY ACCESSION(S): PRJNA350300

REPOSITORIES: GEO

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Publications

Integrative analyses of translatome and transcriptome reveal important translational controls in brown and white adipose regulated by microRNAs.

Reid David W DW   Xu Dan D   Chen Peng P   Yang Hongyuan H   Sun Lei L  

Scientific reports 20170718 1


The epidemic of obesity and diabetes has markedly spurred the research interest in adipocyte biology. Brown adipocytes are specialized for energy expenditure and of therapeutic interest for treatment of metabolic diseases, but how brown adipocytes are distinguished from white adipocytes at the level of translational regulation remains poorly understood. To systemically determine the translational control of gene expression in adipose tissue, we performed ribosome profiling and RNA-seq in paralle  ...[more]

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