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Ultrasonic surgical aspirate is a reliable source for adult neural progenitor cells (aNPCs)

ABSTRACT: Adult neural progenitor cells (aNPCs) are a potential source for cell based therapy for neurodegenerative diseases and traumatic brain injuries. We show that the ultrasonic aspirate samples that are typically considered as a waste after surgery are a great source for aHNPCs.

ORGANISM(S): Homo sapiens

PROVIDER: GSE89201 | GEO | 2017/08/15

SECONDARY ACCESSION(S): PRJNA350674

REPOSITORIES: GEO

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Ultrasonic surgical aspirate is a reliable source for culturing glioblastoma stem cells

Project description:Glioblastoma stem cells (GSCs) are thought to be the source of tumor growth and therapy resistance. Core biosies that are used to generate GSC cultures are ususally taken from one part of the tumor and are thus unlikely to represent intra-tumoral heterogeneity. This study shows that the ultrasonic aspirates (UA), that are usually considered as a biological waste, can be used as a reliable source of GSCs. Furthermore the UA aspirates seem to be capturing the tumorigenic signature better than the traditional biopsies.

2017-02-10 | GSE84707 | GEO

Ultrasonic Surgical Aspirate is a Reliable Source For Culturing Glioblastoma Stem Cells.

Project description: Not available

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Rapid DNA methylation-based classification of pediatric brain tumours from ultrasonic aspirate specimens

Project description:Cavitating ultrasonic aspirator devices are frequently used in pediatric neurosurgery for efficient microsurgical resection of brain tumours while minimizing tissue damage to surrounding healthy brain. Within this study molecular diagnostics using methylation-based classification of ultrasonic aspirated samples was performed and performance against routine microarray diagnostics was assessed.

2024-02-08 | GSE255044 | GEO

FFPE-samples from cavitational ultrasonic surgical aspirates are suitable for RNA profiling of gliomas

Project description:During surgical procedures of gliomas, tissular material obtained from cavitational ultrasonic surgical aspirators (CUSAs) is generally discarded but can exceed amount and quality of certain tumour core resections (TCRs). From archived FFPE-samples, we compared the profiles of somatic mutations and gene expression in the solid material from aspirates and TCRs obtained from the same patients in selected gliomas encompassing grade II to IV. Despite the characteristic heterogeneity of gliomas, we found substantial similarities between the corresponding aspirates and TCRs that included mutations used in the clinical routine and glioma-associated transcriptional signatures. Based on these results, we confirmed the suitability of CUSA-fixed biomaterial from glioma surgeries for downstream applications.

2021-10-20 | GSE166696 | GEO

Evaluation of efficacy and safety of an ultrasonic surgical system and reusable shear for ultrasonic surgical system in colorectal surgery: A prospective, single-center, randomized, open, parallel controlled, non-inferiority trial

Project description:Interventions: Experiment Group A:use the ultrasonic surgical systems (Ezisurg Medical Co., Ltd.) in the colorectal surgery;Experiment Group B:use the reusable shear for ultrasonic surgical system (Ezisurg Medical Co., Ltd.) in the colorectal surgery;Control Group:use the Harmonic Ace+7, 5mm Diameter Shears with Advanced Hemostasis (Ethicon Endo-Surgery,LLC) in the colorectal surgery Primary outcome(s): overall good performance rate Study Design: Parallel

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Evaluation of chromosomal abnormalities and copy number variations in fetuses with ultrasonic soft markers

Project description:This study aimed to evaluate the clinical value of copy number variations (CNVs) in fetuses with ultrasonic soft markers. Among 1131 fetuses, 729 had single ultrasonic soft marker, 322 had two ultrasonic soft markers, and 80 had three or more ultrasonic soft markers. All fetuses underwent single nucleotide polymorphism (SNP) array analysis. Among 1131 fetuses with ultrasonic soft markers, 46 had chromosomal abnormalities. In addition to the 46 fetuses with chromosomal abnormalities consistent with the results of the karyotyping analysis, the SNP array identified additional 6.1% (69/1131) abnormal CNVs. No significant difference was found in the rate of abnormal CNVs among the groups. The SNP array can fully complement conventional karyotyping in fetuses with ultrasonic soft markers, improve detection rate of chromosomal abnormalities, and affect pregnancy outcomes.

2020-12-24 | GSE163799 | GEO

Homo sapiens

Project description:Ultrasonic surgical aspirate is a reliable source for culturing glioblastoma stem cells

| PRJNA330866 | ENA

Homo sapiens

Project description:Ultrasonic surgical aspirate is a reliable source for adult neural progenitor cells (aNPCs)

| PRJNA350674 | ENA

FFPE-samples from cavitational ultrasonic surgical aspirates are suitable for RNA profiling of gliomas

Project description:FFPE-samples from cavitational ultrasonic surgical aspirates are suitable for RNA profiling of gliomas

| PRJNA701629 | ENA

mTOR Inhibition Enables Long-Term Expansion of Human Neonatal Tracheal Aspirate-Derived Airway Basal Stem Cells

Project description:Bronchopulmonary dysplasia remains one of the most common complication of prematurity, despite significant improvements in perinatal care. Functional modeling of human lung development and disease, like BPD, is limited by our ability to access the lung and to maintain relevant stem cell populations in culture. Single cell RNA-sequencing confirmed the presence of epithelial cells in tracheal aspirates obtained from intubated neonates. Using combined SMAD signaling inhibition and mTOR inhibition neonatal tracheal-aspirate derived (nTAD) basal stem cells can be expanded long-term and retain the ability to differentiate into pseudo-stratified airway epithelium. Conclusions: Our data demonstrate that neonatal tracheal aspirate-derived epithelial cells can provide a novel ex vivo human cellular model to study neonatal lung development and disease.

2020-09-21 | GSE137950 | GEO

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