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Functional significance of the HIV-1 Tat signature amino acid residues


ABSTRACT: We sequenced the mRNA from a stably transduced Human T-cell line expressing the HIV-1 Tat protein. The inducible Tat expression has been used to understand and compare the cellular molecules and pathways being modulated by the wild type subtype-C Tat versus its single signature amino acid residue variant. Additionaly, the HIV-1 subtype B and C Tat comparitive analysis has also been included in the study to evaluate the gene expression profile as a reponse to subtype specific Tat proteins. Overall design: Evaluation of the genes and pathways differentially modulated by the epression of the variant HIV-1 Tat proteins or suntype specific Tat proteins in a Human T-cell line using RNASeq analysis.

INSTRUMENT(S): Illumina HiSeq 2000 (Homo sapiens)

ORGANISM(S): Homo Sapiens

SUBMITTER: Ranga Udaykumar  

PROVIDER: GSE89266 | GEO | 2018-10-25

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
GSE89266_Expression_Data_Sample_1-Sample_2-Sample_6.txt.gz Txt
GSE89266_Expression_Data_Sample_3-Sample_4-Sample_6.txt.gz Txt
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