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Transcriptome of human B cell subsets isolated from terminal ileum and spleen

ABSTRACT: Non-switched memory (ME-M) B cells are an enigmatic population of IgM+ memory lymphocytes that are thought to emerge from germinal centers during systemic antibody responses against T cell-dependent antigens. To gain new insights into the properties of ME-M B cells generated during intestinal antibody responses, we performed global gene transcriptome expression analysis on naïve, ME-M and canonical memory class-switched (ME-SW) B cells purified from human gut samples. Marginal zone (MZ) and ME-SW B cells isolated from human spleen samples were used for comparison.

ORGANISM(S): Homo sapiens

PROVIDER: GSE89282 | GEO | 2017/07/27

SECONDARY ACCESSION(S): PRJNA351234

REPOSITORIES: GEO

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