Transcriptomics,Genomics

Dataset Information

40

Novel data integration approaches identify concordant and discordant immune responses between mice and humans [mouse]


ABSTRACT: We have conducted experiments to compare transcriptional response to tuberculosis (TB) in whole blood in two different TB murine models (susceptible 129S2 strain and resistant C57BL/6 strain) in time points day 1, day 7, day 14 and day 21 after infection. Overall design: We collected whole blood samples from two TB murine models (129S2 and C57BL/6 mice), uninfected and at day 1, day 7, day 14 and day 21 p.i. , extracted RNA and performed microarray experiments. There were 5 infected mice of each strain in every time point after infection, 8 control 129S2 non-infected mice and 6 control C57BL/6 non-infected mice.

INSTRUMENT(S): Agilent-028005 SurePrint G3 Mouse GE 8x60K Microarray (Probe Name version)

SUBMITTER: Teresa Domaszewska 

PROVIDER: GSE89389 | GEO | 2017-09-21

SECONDARY ACCESSION(S): PRJNA352057

REPOSITORIES: GEO

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Publications

Concordant and discordant gene expression patterns in mouse strains identify best-fit animal model for human tuberculosis.

Domaszewska Teresa T   Scheuermann Lisa L   Hahnke Karin K   Mollenkopf Hans H   Dorhoi Anca A   Kaufmann Stefan H E SHE   Weiner January J  

Scientific reports 20170921 1


Immunity in infection, inflammation and malignancy differs markedly in man and mouse. Still, we learn about human immunity in large extent from experimental mouse models. We propose a novel data integration approach which identifies concordant and discordant gene expression patterns of the immune responses in heterologous data sets. We have conducted experiments to compare human and murine transcriptional responses to Mycobacterium tuberculosis (Mtb) infection in whole blood (WB) as well as macr  ...[more]

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