Transcriptomics,Genomics

Dataset Information

156

Defining Age- and Lactocrine-Sensitive Elements of the Neonatal Porcine Uterine microRNA-mRNA Interactome


ABSTRACT: Factors delivered to offspring in colostrum within two days of birth support neonatal porcine uterine development. The uterine mRNA transcriptome is affected by age and nursing during this period. Whether uterine microRNA (miRNA) expression is affected similarly is unknown. Objectives were to: 1) determine effects of age and nursing on porcine uterine miRNA expression between birth and postnatal day (PND) 2 using small RNA sequencing (smRNA-Seq) and; 2) define affected miRNA-mRNA interactions and associated biological processes using integrated target prediction analysis. Overall design: Pig uterine tissues were obtained from neonatal gilts (n = 4/group) within 1 h of birth [postnatal day (PND) 0], or 48 h after nursing ad libitum (PND 2N), or feeding a commercial milk replacer (PND 2R).

INSTRUMENT(S): Illumina HiSeq 2500 (Sus scrofa)

SUBMITTER: Caroll Bagnell  

PROVIDER: GSE89414 | GEO | 2017-02-16

SECONDARY ACCESSION(S): PRJNA352081

REPOSITORIES: GEO

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Publications

Defining age- and lactocrine-sensitive elements of the neonatal porcine uterine microRNA-mRNA interactome.

George Ashley F AF   Rahman Kathleen M KM   Camp Meredith E ME   Prasad Nripesh N   Bartol Frank F FF   Bagnell Carol A CA  

Biology of reproduction 20170201 2


Factors delivered to offspring in colostrum within 2 days of birth support neonatal porcine uterine development. The uterine mRNA transcriptome is affected by age and nursing during this period. Whether uterine microRNA (miRNA) expression is affected similarly is unknown. Objectives were to (1) determine effects of age and nursing on porcine uterine miRNA expression between birth and postnatal day (PND) 2 using miRNA sequencing (miRNAseq) and; (2) define affected miRNA–mRNA interactions and asso  ...[more]

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