Analysis of transgenerational effects on DNA copy number aberrations in male mice exposed to continuous 20mGy/day gamma-rays for 400 days (Primary screening for 0mGyA family)

ABSTRACT: Transgenerational effects of continuous low dose-rate (LDR) gamma-ray irradiation have not been well studied. Recent advances in DNA technology enabled us to examine a whole genome at molecular level. Here we adopted one of these techniques called oligo-microarray comparative genome hybridization (CGH) and studied trans-generational effects on DNA copy number aberrations (CNAs). C57BL/6JNrs male mice were exposed to LDR gamma-rays (20 mGy/day) for 400 days (total dose: 8000 mGy) from 8 weeks of age. Progeny from 20 mGy/day irradiated mice had significantly higher frequencies of genomic aberrations than the progeny of non-irradiated mice. This study investigated the De novo mutation by comparing the parents and children using 25 irradiated male family and 25 non irradiated male family. This study was performed under contract with the Aomori Prefectural Government, Japan.

ORGANISM(S): Mus musculus

PROVIDER: GSE89421 | GEO | 2016/11/03

SECONDARY ACCESSION(S): PRJNA352148

REPOSITORIES: GEO