RNA Seq analysis of NKX2-5 Null and Het human embryonic stem cells in cardiomyogenesis

ABSTRACT: Differentiation of human pluripotent stem cells (hPSCs) can be used to model human heart development and, in turn, to analyze the developmental consequences of genetic abnormalities. Here, we deleted NKX2-5, a critical component of the cardiac gene regulatory network, in human embryonic stem cells (hESCs) and identified a novel genetic interaction between NKX2-5 and HEY2 that is required for heart development

ORGANISM(S): Homo sapiens

PROVIDER: GSE89443 | GEO | 2018/03/21

REPOSITORIES: GEO