Genomics

Dataset Information

45

Anti-obesity effect of radix Angelica sinensis and candidate causative genes in transcriptome analyses of adipose tissues in high-fat diet-induced mice


ABSTRACT: We have previously reported that radix Angelica sinensis (RAS) suppressed body weight and altered FTO expression in mice with high fat diet (HFD)-induced obesity. In the present study we performed RNA sequencing-mediated transcriptome analysis to elucidate the molecular mechanisms underlying the anti-obesogenic effects of RAS in mice. The results revealed that 36 differentially-expressed genes (DEGs) were identified between the RAS supplementation group (DH) and control group (HC). These 36 DEGs were clustered into 297 functional gene ontology (GO) categories, among which several GO annotations and signaling pathways were associated with lipid homeostasis. Six out of the 36 DEGs were identified to be involved in lipid metabolism, with the APOA2 gene a potential anti-obesogenic influence. The expression pattern revealed by RNA-Seq was identical to the results of quantitative real-time PCR (qPCR). Therefore, RAS supplementation in HFD-induced obese mice was associated with an anti-obesogenic global transcriptomic response. This study provides insight into potential applications of RAS in obesity therapy. Overall design: Examination ofdifferentially-expressed genes in 2 groups.

INSTRUMENT(S): Illumina Genome Analyzer (Mus musculus)

SUBMITTER: Tao Zhong  

PROVIDER: GSE89454 | GEO | 2016-11-15

SECONDARY ACCESSION(S): PRJNA352249

REPOSITORIES: GEO

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Publications

Anti-obesity effect of radix Angelica sinensis and candidate causative genes in transcriptome analyses of adipose tissues in high-fat diet-induced mice.

Zhong Tao T   Zhang Hao H   Duan Xiaoyue X   Hu Jiangtao J   Wang Linjie L   Li Li L   Zhang Hongping H   Niu Lili L  

Gene 20161110


We have previously reported that radix Angelica sinensis (RAS) suppressed body weight and altered the expression of the fat mass and obesity associated (FTO) gene in mice with high fat diet (HFD)-induced obesity. In the present study we performed RNA sequencing-mediated transcriptome analysis to elucidate the molecular mechanisms underlying the anti-obesogenic effects of RAS in mice. The results revealed that 36 differentially-expressed genes (DEGs) were identified in adipose tissues from the RA  ...[more]

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